- Chris Sanders as Stitch, the main protogonist of the film.
- Nicole Kidman and Sandy Duncan as Angel, Stitch's love interest. She wears a red bow, rose and pink shirt, white skirt, and a round glasses. She speaks with a little lisp and Scottish accent.
- Robin Williams
- Tim Allen
- Gilbert Gottfried
- Wayne Knight
- Malcolm McDowell as Leroy, the antagonist of the film.
- Jim Cummings